Course Description:
Quantitative Chemical Analysis, is one of the basic courses required for chemistry-majored undergraduates. The course is lectured for the first-year undergraduates and provides the students with principles and basic methods as well as practical examples in solving analytical chemistry problems. It covers Introduction to Analytical Chemistry, Data Handling and Analysis, Volumetric Titrations, Gravimetry, Molecular Spectroscopy including UV-Visible Spectroscopy, Molecular Fluorescence and Phosphorescence, Infrared Analysis and Introduction to Raman Spectroscopy) as well as Sample Preparation for Analytical Chemistry. Together with Instrumental Analysis, the course provided a complete lecture series on Analytical Chemistry required for undergraduate students.
Na Li, Ph.D. Professor of Analytical Chemistry |
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1984-1994, BS, MS, and Ph.D. at Peking University; 1994-1998, Peking University 1999-2000, CDDR postdoctoral research fellow, University of Kansas 2000-present Peking University
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Prof. Li’s research interest is Optical sensing methods and applications including, nanoparticle and its composite based spectroscopy (fluorescence, localized surface Plasmon resonance absorption or light-scattering) and the application in biosensing.
Prof. Li has been participating the teaching of quantitative chemical analysis course since 1994. The undergraduate courses she is currently teaching include: Quantitative Chemical Analysis (English), Quantitative Chemical Analysis (discussion), Instrumental Analysis (discussion), and Advanced Analytical Chemistry Topics (discussion).
Prof. Li has edited the English textbook “Quantitative Chemical Analysis” (Peking University Press, 2009) which received excellent textbook of Beijing Higher Education in 2011. The course Quantitative Chemical Analysis (English) was elected the model course for bilingual teaching, Ministry of Education in 2008, and received the excellent teaching prize of Beijing Higher Education in 2008.
李 娜 博士,教授,博士生导师
1988、 1991 和 1994 年先后获北京大学理学学士、硕士和博士学位。
1994-1998 年,北京大学化学学院工作。
1999-2000,美国堪萨斯大学 药化系 CDDR 博士后。
2000至今 北京大学化学学院工作。
研究方向为分子光谱与生化分析,近期的研究兴趣为基于功能化纳米材料的光学生物传感体系的构建、分子识别性质及其在生化分析中的应用。主持国家自然科学基金面上项目4项,法国梅里埃研究院基金1项,教育部留学人员启动基金项目1 项,企业横向项目5项。参加国家自然科学基金重大研究计划培育项目1项,国家自然科学基金重点项目2项,国家自然科学基金面上项目1项,北京大学GF科技培育项目1 项, 科技部863 基金1项。发表SCI收录论文100余篇,其中以通讯作者发表40余篇。
1994年以来参与分析化学教学工作, 包括承担本科生主干基础课《定量化学分析》中英文理论课、《定量化学分析实验》课,以及《仪器分析实验》课的教学任务。是国家级精品课《分析化学系列课程》的骨干教师。2015年3月起任分析化学理论课程主持人。
主讲的《定量化学分析>(英语)获教育部2008年度双语教学示范课程, 以及2008年北京市教育教学成果一等奖。 主编的英文教材Quantitative Chemical Analysis (英文). 于2009年由北京大学出版社,并获2011年北京市精品教材,以及2016年北京大学优秀教材。
Syllabus (Total 32 h, In-class exam 2h, lecture 30 h):
Chapter 1 |
Introduction to Analytical Chemistry (2 lecture hour) Chapter 1 ppt Scope and applications of analytical chemistry; basic calculation |
Chapter 2 |
Data Process and Analysis (3 lecture hours) Chapter 2 ppt Errors in chemical analysis; some important terms; systematic errors; random errors in chemical analysis; the nature of random errors; statistical treatment of random errors; standard deviation of calculated results; report computed data;Statistical data treatment and evaluation; confidence intervals; statistical aids to hypothesis testing; analysis of variance; detection of gross errors; sampling, standardization, and calibration. |
Chapter 3&4 |
Acid-base Equilibria and Neutralization Titration (6 lecture hours) Chapter 3&4 ppt Aqueous solutions and chemical equilibria; effect of electrolytes on chemical equilibria; solving equilibrium problems for complex systems; the composition of acid/base solution as a function of pH; calculating pH of acid/base solution; acid-base buffer; neutralization titrations (monoprotic & polyprotic); calculation of titration error; application examples. |
Chapter 5 |
Complexation and Complexometric Titration (4 lecture hours) Chapter 5 ppt Complexation equilibria; Principle for complexation titration; selective titration; application of complexation titration |
Chapter 6 |
Oxidization-Reduction Equilibria and Redox Titration (3 lecture hours) Chapter 6 ppt Oxidation/reduction reactions in electrochemical cells; Nernst equation, electrode potentials; application of standard electrode potential; calculating potentials of electrochemical cells; calculating redox equilibrium constant; constructing redox titration curves; applications of oxidation/reduction titrations. |
Chapter 7 |
Precipitation Equilibria, Precipitation Titration Gravimetry (2 lecture hour) Chapter 7 ppt Precipitation equilibria; titration by forming precipitation; obtaining precipitation in order to determine sample by weighing; the key to success for this two methods. |
Chapter 8 |
Spectrophotometry (8 lecture hours) Chapter 8 ppt1 ppt2 Light and its interaction with matter; mechanism of molecular absorption, fluorescence and phosphorescence, Raman scattering; type of transition and absorption with organic compound; polar solvent on absorption spectra with instrumentation; mechanism of molecular absorption, fluorescence and phosphorescence, as well as Raman scattering; Instrumentations for UV-vis spectrophotometer, fluorimeter, FTIR spectrophotometer, Raman spectrometer. |
Chapter 9 |
Introduction of Separation Methods in Quantitative Analysis (1 lecture hours) Chapter 9 ppt Introduction; Precipitation based separation; Solvent extraction |
Chapter 10 |
Solving Real Analytical Problems (1 lecture hour) Chapter 10 ppt Examples to illustrate how to solve a real analytical problem |
Homework due date:
Before 5:00 PM on each lecture day
Two notebooks for homework, with name and student ID
Office Hours: to be decided at the beginning of the course
Summative assessment::
Mid-Term 35%; final 50%; homework 10%; term paper or Oral Presentation 5% on given topics
Text Books:
Quantitative Chemical Analysis | |
李娜, John J. Hefferren, 李克安 | |
北京大学出版社, 2009.10. | |
Fundamental of Analytical Chemistry (8th ed) | |
D. A. Skoog, et al | |
Fortworth: Saunders College Pub., 2004. |
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Principles of Instrumental Analysis (6th ed) | |
D. A. Skoog et al. | |
Thomson Brooks/Cole, 2007 | |
Reference Books:
1. Quantitative Chemical Analysis. Na Li,J.J. Hefferren,Ke’an Li,Peking University Press,2009
2. Analytical Chemistry Course, Edited by Li Ke’an, Peking University Press, 2005
3. Analytical Chemistry Course – Problems and Solutions, Edited by Li Ke’an, Peking University Press, 2006
4. Analytical Chemistry—The Concise Textbook of Quantitative Chemical Analysis (Third Edition). Peng Chonghui, Feng Jianzhang, Zhang Xiyu, Li Ke’an and Zhao Fenglin, Peking University Press, 2009
5. Concise Textbook of Quantitative Chemical Analysis (Second Edition). Peng Chonghui, Feng Jianzhang, Zhang Xiyu, Li Ke’an and Zhao Fenglin, Peking University Press, 1997
6. Analytical Chemistry I (Lecture Slides CD ROM) Li Na, Liu Feng, Zhao Fenglin, and Li Ke’an, Peking University Press, 2007
7. Fundamentals of Analytical Chemistry Laboratory (Second Edition). Peking University Analytical
Chemistry Teaching Group. Peking University Press, 1997
8. Fundamentals of Analytical Chemistry (Eighth Edition). D. A. Skoog, D. M. West, F. J. Holler, S. R. Crouch, Brooks Cole, 2004
9. Principle of Instrumental Analysis (Fifth Edition), D.A. Skoog, S.R. Stanley, F.J. Holler, Saunders College Publishing/Harcourt Brace College Publishers, 1998
10. Quantitative Chemical Analysis (Forth Edition). I. M. Kolthoff, Macmillan, 1969